Table of Contents
- 1 What elements does ibuprofen contain?
- 2 Is Ibuprofen a compound or element?
- 3 What is the pKa of ibuprofen?
- 4 Is ibuprofen a polyethylene glycol?
- 5 How is ibuprofen metabolised?
- 6 What is polyethylene glycol made from?
- 7 What is antifreeze made of?
- 8 What makes up the chemical composition of ibuprofen?
- 9 What kind of Medicine is ibuprofen used for?
- 10 Who was the first person to invent ibuprofen?
What elements does ibuprofen contain?
Ibuprofen tablets contain the active ingredient Ibuprofen, which is (±) – 2 – (p – isobutylphenyl) propionic acid. Ibuprofen is a white powder with a melting point of 74-77°C and is very slightly soluble in water (<1 mg/mL) and readily soluble in organic solvents such as ethanol and acetone.
Is Ibuprofen a compound or element?
What is ibuprofen derived?
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin.
What is the pKa of ibuprofen?
Ibuprofen has a pKa of 4.43±0.03 and an n-octanol/water partition coefficient of 11.7 at pH 7.4. The chemical name for ibuprofen is (±)-2-(p-isobutylphenyl) propionic acid. The molecular weight of ibuprofen is 206.28.
Is ibuprofen a polyethylene glycol?
The solubility of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is enhanced by synthesizing ibuprofen ester with a water-soluble polymer, poly(ethylene glycol) (PEG), and the product obtained functions as a nonionic surfactant (IBF-PEG800, IP800).
Is ibuprofen ionic or covalent?
Example 1: Computing Molecular Mass for a Covalent Compound Ibuprofen, C13H18O2, is a covalent compound and the active ingredient in several popular nonprescription pain medications, such as Advil and Motrin.
How is ibuprofen metabolised?
Ibuprofen is almost completely metabolized, with little to no unchanged drug found in the urine [1,9,12]. The primary route of elimination is oxidative metabolism by CYP enzymes to inactive metabolites (Fig. 1).
What is polyethylene glycol made from?
Polyethylene glycol (PEG) is made from ethylene glycol (ethane-1,2-diol), the main ingredient in antifreeze. The general molecular formula for PEG is H(OCH2CH2)nOH, where n represents the number of ethylene glycol units contained in the PEG polymer. PEGs have many industrial, food and pharmaceutical uses.
Is Ibuprofen a polyethylene glycol?
What is antifreeze made of?
What is antifreeze? A glycol-based fluid made primarily from ethylene glycol or propylene glycol, antifreeze is one of the components of the fluid used in the cooling system of your car.
What makes up the chemical composition of ibuprofen?
Composition of Ibuprofen is composed of cellulose, corn starch, fumed silica jell, hypromellose, lactose, magnesuim stearate, polydextrose, polythylen gylcol, povidone, silica, sodium starch glycolate, stearic acid, titanium dioxide, and triacetine. Ibuprofen is mainly made of cellulose and corn starch.
What are the inactive ingredients in Ibuprofen pills?
What Are the Ingredients in Ibuprofen? Ibuprofen is derived from propionic acid. It is a white powder that is made into pill form for oral administration. Other inactive ingredients in ibuprofen pills include polydextrose, titanium dioxide, colloidal silicon dioxide and hypromellose.
What kind of Medicine is ibuprofen used for?
Ibuprofen is a medication in the nonsteroidal anti-inflammatory drug (NSAID) class that is used for treating pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. It may also be used to close a patent ductus arteriosus in a premature baby.
Who was the first person to invent ibuprofen?
It is a relatively simple molecule that was discovered and developed in the 1950s and 1960s at Boots Pure Drug in Nottingham, UK (now Boots UK in Beeston). The initial British patent on ibuprofen and a long list of similar compounds was awarded to John Nicholson and Stewart Adams of Boots in 1964.